他汀类药物治疗主动脉瓣狭窄有证据支持吗？
Is there evidence for statins in the treatment of aortic valve stenosis?
作者信息
Akin Ibrahim, Nienaber Christoph A
机构信息
Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany.
Royal Brompton Hospital and Harefield Trust, London SW3 6NP, United Kingdom.
出版信息
World J Cardiol. 2017 Aug 26;9(8):667-672. doi: 10.4330/wjc.v9.i8.667.
Abstract
Research revealed that the pathogenesis of aortic stenosis (AS) not merely comprises of a mechanical wear and tear process yet that active biological processes, similar to those of coronary artery disease are involved, a promising role for statins in disease-modifying therapy was suggested. However, recently, many prospective studies could not observe decreased progression nor regression of the disease. Here, we review the current knowledge on the pathomechanisms of AS and its similarities and differences with atherosclerosis. Moreover, we discuss whether there is still a place for statins in the treatment of particular AS patient subgroups.
摘要
研究表明，主动脉瓣狭窄（AS）的发病机制不仅包括机械磨损过程，还涉及与冠状动脉疾病类似的活跃生物学过程，这提示他汀类药物在疾病修饰治疗中可能发挥作用。然而，最近许多前瞻性研究未能观察到疾病进展减缓或病情逆转。在此，我们综述了目前关于AS发病机制及其与动脉粥样硬化异同的知识。此外，我们还讨论了他汀类药物在特定AS患者亚组治疗中是否仍有一席之地。
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