Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, C/Casanova 143, 08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/ Villarroel 170, 08036 Barcelona, Spain; Clinical Institute of Neurosciences (ICN), Hospital Clinic, C/ Villarroel 170, 08036 Barcelona, Spain.
Psychiatry Res. 2013 Nov 30;214(2):94-101. doi: 10.1016/j.pscychresns.2013.06.008. Epub 2013 Aug 29.
Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysis and surface-based morphometry to 14 patients with schizophrenia and 14 healthy controls. Neurocognitive functioning was assessed by a neuropsychological test battery that measured executive function. It was hypothesized that working memory dysfunctional connectivity in schizophrenia is related to underlying anatomical abnormalities. Patients with schizophrenia showed cortical thinning in the left inferior frontal gyrus and insula, which explained 57% of blood oxygenation level-dependent signal magnitude in functional magnetic resonance imaging in the central executive network (lateral prefrontal and parietal cortex) over-activation and default mode network (anterior and posterior cingulate) deactivation. No structure-function relationship emerged in the healthy control group. The study provides evidence to suggest that dysfunctional activation/deactivation patterns in schizophrenia may be explained in terms of underlying gray matter deficits.
虽然工作记忆在精神分裂症中已知受损，但这种缺陷的解剖学和功能关系仍有待阐明。采用涉及功能和结构磁共振技术的联合成像方法，对 14 名精神分裂症患者和 14 名健康对照者进行了独立成分分析和基于表面的形态测量。通过测量执行功能的神经心理学测试组合评估神经认知功能。假设精神分裂症的工作记忆功能连接障碍与潜在的解剖异常有关。精神分裂症患者的左侧额下回和脑岛皮质变薄，这解释了中央执行网络（外侧前额叶和顶叶皮层）过度激活和默认模式网络（前后扣带回）失活时功能磁共振成像中血氧水平依赖信号幅度的 57%。健康对照组中没有出现结构-功能关系。该研究提供的证据表明，精神分裂症中功能失调的激活/失活模式可以用潜在的灰质缺陷来解释。
