Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA.
Hum Immunol. 2013 Dec;74(12):1656-8. doi: 10.1016/j.humimm.2013.08.280. Epub 2013 Aug 29.
GM and KM allotypes-hereditary antigenic variants of immunoglobulin γ and κ chains, respectively-and the genetic variants of activating Fcγ receptors (FcγR) are associated with the immunobiology of several malignant diseases, but their role in susceptibility to prostate cancer has not been examined. This investigation aimed to determine whether these genes-individually or in particular epistatic combinations-contribute to the risk of prostate cancer. We genotyped DNA from 200 Caucasian patients with prostate cancer and 185 healthy controls (matched for age, race, gender, and geography) for several GM, KM, FcγRIIa, and FcγRIIIa alleles by molecular methods. None of the genotypes by itself was associated with the risk of prostate cancer. However, particular alleles at GM 23 and FcγRIIa loci interactively contributed to the risk of this malignancy (p = 0.031), the odds ratios ranging from 0.44 in subjects homozygous for the GM 23- allele at the IgG2 locus and for the histidine allele at the FcγRIIa locus to 2.86 in subjects homozygous for the GM 23+ allele at the IgG2 locus and the histidine allele at the FcγRIIa locus. To our knowledge, this is the first report implicating GM and FcγR loci as risk/protective factors for prostate cancer. Additional, independent, studies are warranted to confirm and extend these findings.
GM 和 KM 同种异型 - 免疫球蛋白 γ 和 κ 链的遗传抗原变体，以及激活 Fcγ 受体（FcγR）的遗传变异体与几种恶性疾病的免疫生物学有关，但它们在前列腺癌易感性中的作用尚未得到研究。本研究旨在确定这些基因 - 单独或在特定的上位性组合中 - 是否会导致前列腺癌的风险。我们通过分子方法对 200 名白种人前列腺癌患者和 185 名健康对照者（年龄、种族、性别和地理匹配）的 DNA 进行了 GM、KM、FcγRIIa 和 FcγRIIIa 等位基因的基因分型。单独的基因型本身与前列腺癌的风险无关。然而，GM 23 和 FcγRIIa 基因座的特定等位基因与这种恶性肿瘤的风险具有交互作用（p = 0.031），其比值范围从 GM 23- 等位基因在 IgG2 基因座和 FcγRIIa 基因座的组氨酸等位基因的纯合子的 0.44 到 GM 23+ 等位基因在 IgG2 基因座和 FcγRIIa 基因座的组氨酸等位基因的纯合子的 2.86。据我们所知，这是首次报道 GM 和 FcγR 基因座作为前列腺癌的风险/保护因素。需要进一步的、独立的研究来证实和扩展这些发现。
