Department of Pharmaceutical Technology and Biopharmaceutics, Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688 Krakow, Poland.
Int J Pharm. 2013 Nov 18;456(2):569-71. doi: 10.1016/j.ijpharm.2013.08.004. Epub 2013 Aug 28.
The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating. Proposed method involves evaluation of enteric coated model tablets in specially designed testing cell with application of MRI technique. The results obtained in the testing cell were compared with results of dissolution studies of mini-tablets coated in fluid bed apparatus. The method could be useful in early stage of formulation development for screening of film coating properties that will shorten and simplify the development works.
本研究旨在提出一种新方法的概念，用于快速筛选肠溶性包衣组合物的特性，而无需为流化床包衣制备片剂批次。所提出的方法涉及在带有 MRI 技术的特殊设计的测试单元中评估肠溶包衣模型片剂。在测试单元中获得的结果与在流化床设备中包衣的微型片剂的溶解研究结果进行比较。该方法可用于配方开发的早期阶段，用于筛选薄膜包衣性能，从而缩短和简化开发工作。
