基于人群的斯洛文尼亚宫颈筛查计划中女性中 15 种人乳头瘤病毒（HPV）型的疫苗接种前血清流行率。
Pre-vaccination seroprevalence of 15 human papillomavirus (HPV) types among women in the population-based Slovenian cervical screening program.
机构信息
Department of Communicable Diseases and Environmental Threats, National Institute of Public Health, Trubarjeva 2, 1000 Ljubljana, Slovenia.
出版信息
Vaccine. 2013 Oct 9;31(43):4935-9. doi: 10.1016/j.vaccine.2013.08.038. Epub 2013 Aug 29.
OBJECTIVES
To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program.
METHODS
Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex).
RESULTS
Seropositivity for any of the 15 HPV types was 65.7%, any of the 11 hr-HPV types 59.2%, and any of the four lr-HPV types 33.1%. Antibodies against at least one of the four vaccine HPV types (HPV 6, 11, 16, 18) were detected in 40.8% women. Among hr-HPV types, seropositivity was highest for HPV 16 (25.2%) and among lr-HPV types for HPV 6 (19.1%). Age-specific HPV16 seropositivity was highest among 30-39 years old (29.6%) and decreased with increasing age to 14.0% among 60-64 years old.
CONCLUSION
The lifetime sexual exposure to genital HPV types is substantial, emphasising the need for HPV vaccination.
目的
评估参与基于人群的宫颈癌筛查计划的 20-64 岁斯洛文尼亚女性中 11 种高危（hr）HPV 型和 4 种低危（lr）HPV 型的血清流行率。
方法
使用基于多重假病毒的血清学检测（PsV-Luminex）对 3259 名女性的血清样本进行 HPV 型特异性抗体检测。
结果
15 种 HPV 型中的任何一种的血清阳性率为 65.7%，11 种 hr-HPV 型中的任何一种为 59.2%，4 种 lr-HPV 型中的任何一种为 33.1%。至少有一种四种疫苗 HPV 型（HPV 6、11、16、18）的抗体在 40.8%的女性中被检测到。在 hr-HPV 型中，血清阳性率最高的是 HPV 16（25.2%），在 lr-HPV 型中，血清阳性率最高的是 HPV 6（19.1%）。HPV16 的年龄特异性血清阳性率在 30-39 岁年龄组中最高（29.6%），随着年龄的增长而降低，在 60-64 岁年龄组中降至 14.0%。
结论
一生中接触生殖道 HPV 型的情况很多，这强调了 HPV 疫苗接种的必要性。
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