Nikitina A V, Fedorova N V
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(7 Pt 2):32-8.
Dopaminergic replacement therapy (DRT) is effective in treatment the motor symptoms of Parkinson's disease (PD) but can lead to impulse control disorders (ICD) in some patients. ICD include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding, dopamine dysregulation syndrome (DDS). Authors studied the prevalence of ICD and its impact on the quality of life and daily activities of PD patients and their relatives. Among 246 patients studied, 55 patients (23%) (28 men, mean age 66.5±9.4 years) were diagnosed with ICD. DDS was noted in 36.4%, punding in 36.4%, binge eating in 23.6%, hypersexuality in 14.5%, compulsive shopping in 14.5% and pathological gambling in 1.8%. Of these 55 patients, 10 (18.1%) had symptoms of 2 of the ICDs: 3 (5.45%) had 3 of the ICDs and 2 (3.63%) patients had 5 of the ICDs. Quality of life ranged from 25% to 89%. Treatment approaches including the adjustment of doses of levodopa and dopamine receptor agonists in PD patients with ICD are presented.
多巴胺能替代疗法（DRT）对治疗帕金森病（PD）的运动症状有效，但在一些患者中可能导致冲动控制障碍（ICD）。ICD包括病理性赌博、性欲亢进、强迫性购物、暴饮暴食、刻板动作、多巴胺调节障碍综合征（DDS）。作者研究了ICD的患病率及其对PD患者及其亲属生活质量和日常活动的影响。在246例研究患者中，55例（23%）（28名男性，平均年龄66.5±9.4岁）被诊断为ICD。DDS占36.4%，刻板动作占36.4%，暴饮暴食占23.6%，性欲亢进占14.5%，强迫性购物占14.5%，病理性赌博占1.8%。在这55例患者中，10例（18.1%）有2种ICD症状：3例（5.45%）有3种ICD症状，2例（3.63%）患者有5种ICD症状。生活质量范围为25%至89%。本文介绍了针对有ICD的PD患者调整左旋多巴和多巴胺受体激动剂剂量等治疗方法。
