Molina Vicente, Blanco José A
Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain.
J Nerv Ment Dis. 2013 Sep;201(9):744-52. doi: 10.1097/NMD.0b013e3182a21444.
The current schizophrenia concept is built on experts' agreement on the matter, and it is basically rooted in the epidemiological and clinical evidence. However, the numerous and intensive attempts to find the biological underpinnings of this syndrome face almost constantly a low degree of replication of the results. We have reviewed previously published work to contribute to identify some reasons underlying that failure. The difficulty in replicating biological findings in schizophrenia may relate to the intrinsic heterogeneity among patient samples, acquired through the current diagnostic criteria. As a result, the necessary replication for any finding to be accepted as characteristic data for schizophrenia would be impeded. Therefore, a new frame based on identification of correlates of the most replicated biological anomalies in schizophrenia to date may contribute to overcome those difficulties.
当前的精神分裂症概念建立在专家对此事的共识之上，并且基本上植根于流行病学和临床证据。然而，为寻找该综合征生物学基础所做的大量且深入的尝试几乎一直面临着研究结果低重复性的问题。我们回顾了之前发表的研究工作，以探究导致这种失败的一些潜在原因。精神分裂症生物学研究结果难以复制，可能与通过当前诊断标准获取的患者样本内在异质性有关。因此，任何研究结果要被接受为精神分裂症的特征性数据所必需的重复性将受到阻碍。所以，基于识别迄今为止精神分裂症中最具重复性的生物学异常相关因素建立一个新框架，可能有助于克服这些困难。
