Lechat P
Institut de Pharmacologie, Paris.
Therapie. 1990 Jul-Aug;45(4):341-6.
Animal experiments are scientifically justified to establish kinetic parameters of xenobiotics in vivo (absorption, diffusion, biotransformation, elimination of pesticides, food additives and drugs). They are indispensable for evaluating toxic effects which appear with delay (carcinogenesis, drug dependence), and for exploring reactions which involve complex regulating systems in the whole organism. In this field, methods are in progress, leading to use less and less animals and to obtain more accurate data. Some problems still exist concerning painful experiments and controls of local tolerance. In vitro assays must not be opposed against those performed in vivo, since both are complementary and must be coordinated in order to make fruitful progresses for the benefit of men but also of animals.
进行动物实验在科学上是合理的，目的是确定体内外源性物质的动力学参数（吸收、扩散、生物转化、农药、食品添加剂和药物的消除）。对于评估延迟出现的毒性作用（致癌作用、药物依赖性）以及探索涉及整个生物体复杂调节系统的反应而言，动物实验不可或缺。在这一领域，正在研发一些方法，以减少动物的使用数量并获得更准确的数据。在痛苦实验和局部耐受性控制方面仍然存在一些问题。体外试验不应与体内试验相对立，因为两者是互补的，必须相互协调，以便为人类和动物带来有益的丰硕进展。
