Polizzi Karen M
Centre for Synthetic Biology and Innovation, Department of Life Sciences, Imperial College, London, London, UK.
Methods Mol Biol. 2013;1073:3-6. doi: 10.1007/978-1-62703-625-2_1.
Synthetic biology is a rapidly developing field that aims to engineer new biological systems that do not already exist in Nature or redesign existing systems from scratch. The emergence of synthetic biology has been supported by a number of enabling technologies and what has developed is a broad field that currently encompasses many activities. The aim of this chapter is to introduce the field and discuss some key examples to date. What these examples have in common is a set of underlying molecular biology techniques including DNA assembly and combinatorial diversity generation, as well as computational modelling to assist in designing the new biological systems.
合成生物学是一个快速发展的领域，旨在设计自然界中尚不存在的新型生物系统，或从零开始重新设计现有系统。合成生物学的出现得益于多项使能技术，其发展成为了一个广泛的领域，目前涵盖了许多活动。本章的目的是介绍该领域，并讨论一些迄今为止的关键实例。这些实例的共同之处在于一系列基础分子生物学技术，包括DNA组装和组合多样性生成，以及用于辅助设计新型生物系统的计算建模。
