Wang Ruimin, Zhu Haiyan, Chen Yingmao, Li Can, Li Fei, Shen Zhihui, Tian Jiahe, Yu Li, Xu Baixuan
Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.
Hematol Oncol. 2014 Sep;32(3):126-32. doi: 10.1002/hon.2093. Epub 2013 Sep 1.
Although (18) F-FDG PET/CT imaging is the conventional method for evaluating lymphoma, PET/CT imaging with radiopharmaceuticals other than FDG is being investigated. We evaluated the utility of different standardized uptake value (SUV) measurements in (18) F-FLT PET/CT scans compared with PET/CT scans performed with FDG. Two scans, each using one of the radiopharmaceuticals, were performed on each of 114 patients with histologically proven lymphoma. Maximum and mean SUV (SUV(max)) and (SUV(mean)) of all visualized lesions, with backgrounds of mediastinal blood pool, liver, spleen and vertebra were calculated. The ratios of the SUVs of the lesions to those of each reference region were statistically analyzed. Using receiver operating characteristic curves, we analyzed the differences in uptake of the two agents in aggressive and indolent B-cell non-Hodgkin lymphoma. We found that the SUV(max) measurements of FDG were significantly different between aggressive and indolent B-cell non-Hodgkin lymphoma. The receiver operating characteristic curve of SUV(max) of tumour/liver for FDG studies resulted in the most area under the curve. The SUV(max) of the tumour/mediastinum ratio for FLT studies resulted in the most area under the curve (0.781). There was no significant correlation between FDG and FLT uptake in most types of lymphoma we studied. Further studies of the characteristics of (18) F-FLT should employ the tumour/mediastinum SUV(max) ratio for accurate uptake measurement.
尽管（18）F-FDG PET/CT成像术是评估淋巴瘤的传统方法，但目前正在研究使用除FDG之外的放射性药物进行PET/CT成像。我们评估了（18）F-FLT PET/CT扫描中不同标准化摄取值（SUV）测量方法的效用，并与使用FDG进行的PET/CT扫描进行比较。对114例经组织学证实患有淋巴瘤的患者均进行了两次扫描，每次扫描使用一种放射性药物。计算所有可见病灶的最大和平均SUV（SUV（max）和SUV（mean）），并以纵隔血池、肝脏、脾脏和椎骨作为背景。对病灶与各参考区域的SUV比值进行统计学分析。利用受试者工作特征曲线，我们分析了侵袭性和惰性B细胞非霍奇金淋巴瘤中两种药物摄取的差异。我们发现，侵袭性和惰性B细胞非霍奇金淋巴瘤之间FDG的SUV（max）测量值存在显著差异。FDG研究中肿瘤/肝脏SUV（max）的受试者工作特征曲线下面积最大。FLT研究中肿瘤/纵隔比值的SUV（max）曲线下面积最大（0.781）。在我们研究的大多数类型淋巴瘤中，FDG和FLT摄取之间无显著相关性。对（18）F-FLT特征的进一步研究应采用肿瘤/纵隔SUV（max）比值进行准确的摄取测量。
