Vagner R I, Kozlov A P, Moskalik K G
Vopr Onkol. 1990;36(7):859-62.
A procedure for stage I skin melanoma treatment using pulsed laser radiation was developed and employed in 94 patients. At first, a delimiting barrier around tumor was formed with laser beam. It was followed by incision biopsy of melanoma under local anesthesia to morphologically assess level of invasion (after Clark) and thickness of tumor (according to Breslow). Finally, tumor was destroyed with laser beam. The observed rates of metastasis development and 5-year survival and duration of metastasis-free period suggest that the treatment did not provoke tumor dissemination. Moreover, the procedure offered certain advantages over other therapeutic modalities for skin melanoma employing pulsed laser radiation.
开发了一种使用脉冲激光辐射治疗I期皮肤黑色素瘤的方法，并应用于94例患者。首先，用激光束在肿瘤周围形成一个界定屏障。随后在局部麻醉下对黑色素瘤进行切开活检，以形态学评估浸润水平（根据克拉克法）和肿瘤厚度（根据布雷斯洛法）。最后，用激光束摧毁肿瘤。观察到的转移发生率、5年生存率和无转移期持续时间表明，该治疗并未引发肿瘤播散。此外，与其他采用脉冲激光辐射治疗皮肤黑色素瘤的方法相比，该方法具有一定优势。
