[小剂量右美托咪定对脊柱手术患者恢复的影响]

[Influence of small-dose dexmedetomidine on recovery of patients undergoing vertebral operation].

作者信息

Tan Zhimin, Peng Aixia, Yuan Qinghua, Duan Lu, Li Yujuan

机构信息

Department of Anesthesiology, Conghua Central Hospital, Guangzhou 510900, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2013 Aug;33(8):1194-8.

PMID:23996765

Abstract

OBJECTIVE

To evaluate the influence of small-dose dexmedetomidine infusion on recovery of patients undergoing vertebral operation.

METHODS

Sixty ASA I-II patients undergoing vertebral operation were randomly divided into two groups (n=30). In group I, dexmedetomidine infusion was pumped at the rate of 0.5 µg·kg(-1)·h(-1) from tracheal intubation to incision suture, and in group II, 0.9%saline was pumped instead. The mean arterial pressure, heart rate, Riker Sedation-Agitation Scale and Ramesay sedation score were recorded at the time points of autonomous respiration (T1), eye opening (T2), extubation (T3), 1 min after extubation (T4), 10 min after extubation (T5), and 30 min after extubation (T6).

RESULTS

The recovery time of autonomous respiration and eye opening time in group I were significantly longer than those in group II, and the extubation time was significantly shorter in group I (P<0.05). Riker Sedation-Agitation Scale scores in group II were significantly higher than those in group I at T2 and T4, and Ramesay sedation scores in group I were significantly higher than those in group II at T1, T2 and T5 (P<0.05). The mean arterial pressure and heart rate at each time point was significantly lower in group I than in group II (P<0.05), especially at T3 and T4 (P<0.01). In both groups, the mean arterial pressure and heart rate at T3 and T4 were significantly higher than those at rest (P<0.05).

CONCLUSIONS

Small-dose dexmedetomidine infusion can reduce dysphoria and lower the risks during recovery from general anesthesia following vertebral operation.

摘要

目的

评估小剂量右美托咪定输注对椎体手术患者恢复的影响。

方法

将60例接受椎体手术的美国麻醉医师协会（ASA）分级为I-II级的患者随机分为两组（n = 30）。I组从气管插管至切口缝合期间以0.5μg·kg⁻¹·h⁻¹的速率泵注右美托咪定，II组则泵注0.9%生理盐水。在自主呼吸（T1）、睁眼（T2）、拔管（T3）、拔管后1分钟（T4）、拔管后10分钟（T5）和拔管后30分钟（T6）时间点记录平均动脉压、心率、Riker镇静-躁动评分和Ramsay镇静评分。

结果

I组自主呼吸恢复时间和睁眼时间显著长于II组，I组拔管时间显著短于II组（P < 0.05）。II组在T2和T4时的Riker镇静-躁动评分显著高于I组，I组在T1、T2和T5时的Ramsay镇静评分显著高于II组（P < 0.05）。I组各时间点的平均动脉压和心率均显著低于II组（P < 0.05），尤其是在T3和T4时（P < 0.01）。两组在T3和T4时的平均动脉压和心率均显著高于静息时（P < 0.05）。