聚合物纳米粒用于药物和小干扰 RNA 的递送来治疗不同表型的癌症。
Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.
机构信息
Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
出版信息
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):40-60. doi: 10.1002/wnan.1242. Epub 2013 Aug 31.
Abstract
Advances in nanotechnology have provided powerful and efficient tools in the development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles have attracted a considerable attention for their ability to function as a possible carrier for target-specific delivery of various drugs, genes, proteins, peptides, vaccines, and other biomolecules in humans without much toxicity. This review will specifically focus on the recent advances in polymer-based nanocarriers for various drugs and small silencing RNA's loading and delivery to treat different types of cancer.
摘要
纳米技术的进步为癌症的诊断和治疗提供了强大而有效的工具。目前有许多纳米载体已被批准用于癌症治疗的临床应用。近年来，可生物降解的聚合物纳米粒子因其能够作为各种药物、基因、蛋白质、肽、疫苗和其他生物分子的靶向递释载体而受到广泛关注，而其毒性则较低。本综述将特别关注用于各种药物和小干扰 RNA 负载和递送至治疗不同类型癌症的基于聚合物的纳米载体的最新进展。
相似文献
1
Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.聚合物纳米粒用于药物和小干扰 RNA 的递送来治疗不同表型的癌症。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):40-60. doi: 10.1002/wnan.1242. Epub 2013 Aug 31.
2
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.癌症的先进靶向疗法：药物纳米载体，化疗的未来。
Eur J Pharm Biopharm. 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. Epub 2015 Mar 23.
3
Recent advances in siRNA delivery for cancer therapy using smart nanocarriers.利用智能纳米载体实现癌症治疗的 siRNA 传递的最新进展。
Drug Discov Today. 2018 Apr;23(4):900-911. doi: 10.1016/j.drudis.2018.01.042. Epub 2018 Jan 31.
4
Theranostic Nanoparticles for RNA-Based Cancer Treatment.基于 RNA 的癌症治疗用治疗诊断纳米颗粒。
Acc Chem Res. 2019 Jun 18;52(6):1496-1506. doi: 10.1021/acs.accounts.9b00101. Epub 2019 May 28.
5
Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma.用于肝细胞癌治疗药物和小干扰RNA靶向递送的纳米颗粒
World J Gastroenterol. 2015 Nov 14;21(42):12022-41. doi: 10.3748/wjg.v21.i42.12022.
6
Nanoparticle Delivery Systems for DNA/RNA and their Potential Applications in Nanomedicine.纳米颗粒给药系统用于 DNA/RNA 及其在纳米医学中的潜在应用。
Curr Top Med Chem. 2019;19(27):2507-2523. doi: 10.2174/1568026619666191024170212.
7
A strategy using mesoporous polymer nanospheres as nanocarriers of Bcl-2 siRNA towards breast cancer therapy.介孔聚合物纳米球作为 Bcl-2siRNA 纳米载体用于乳腺癌治疗的策略。
J Mater Chem B. 2019 Jan 21;7(3):477-487. doi: 10.1039/c8tb02463d. Epub 2018 Dec 20.
8
Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine.肿瘤酸度裂解马来酸酰胺（TACMAA）：设计智能纳米粒子克服癌症纳米医学中输送障碍的强大工具。
Acc Chem Res. 2018 Nov 20;51(11):2848-2856. doi: 10.1021/acs.accounts.8b00195. Epub 2018 Oct 15.
9
Nanomedicine for cancer: lipid-based nanostructures for drug delivery and monitoring.癌症的纳米医学：用于药物递送和监测的基于脂质的纳米结构。
Acc Chem Res. 2011 Oct 18;44(10):1080-93. doi: 10.1021/ar200011r. Epub 2011 Jul 26.
10
Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy.通过负载 siRNA 的精氨酸修饰的磷酸钙纳米粒沉默survivin 和 cyclin B1 用于非小细胞肺癌治疗。
Colloids Surf B Biointerfaces. 2020 Dec;196:111340. doi: 10.1016/j.colsurfb.2020.111340. Epub 2020 Aug 27.
引用本文的文献
1
Membrane-modified lipid nanoparticles for RNA delivery.用于RNA递送的膜修饰脂质纳米颗粒。
Mol Ther Methods Clin Dev. 2025 Jun 9;33(3):101505. doi: 10.1016/j.omtm.2025.101505. eCollection 2025 Sep 11.
2
Gold Nanoparticles Synthesized with Triple-Negative Breast Cancer Cell Lysate Enhance Antitumoral Immunity: A Novel Synthesis Method.用三阴性乳腺癌细胞裂解物合成的金纳米颗粒增强抗肿瘤免疫：一种新型合成方法。
Pharmaceuticals (Basel). 2025 Feb 26;18(3):330. doi: 10.3390/ph18030330.
3
The Plethora of RNA-Protein Interactions Model a Basis for RNA Therapies.大量的RNA-蛋白质相互作用为RNA疗法奠定了基础。
Genes (Basel). 2025 Jan 2;16(1):48. doi: 10.3390/genes16010048.
4
RNA Structure: Past, Future, and Gene Therapy Applications.RNA结构：过去、未来及基因治疗应用
Int J Mol Sci. 2024 Dec 26;26(1):110. doi: 10.3390/ijms26010110.
5
Gemcitabine and synthesized silver nanoparticles impact on chemically induced hepatocellular carcinoma in male rats.吉西他滨与合成银纳米颗粒对雄性大鼠化学诱导肝细胞癌的影响。
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241263352. doi: 10.1177/03946320241263352.
6
Challenges and advances of the stability of mRNA delivery therapeutics.mRNA递送疗法稳定性的挑战与进展
Nucl Acid Insights. 2024 Mar;1(2):101-113. doi: 10.18609/nai.2024.015. Epub 2024 Mar 13.
7
The Multifaceted Role of miR-21 in Pancreatic Cancers.miR-21 在胰腺癌细胞中的多效作用。
Cells. 2024 May 30;13(11):948. doi: 10.3390/cells13110948.
8
Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery.壳聚糖/海藻酸钠基纳米粒子用于抗菌剂递送。
Int J Nanomedicine. 2024 May 30;19:5021-5044. doi: 10.2147/IJN.S469572. eCollection 2024.
9
Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer.用于癌症治疗的纳米技术集成创新药物递送与疗法
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010279483240417050548.
10
Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice.制备纳米晶体以增强脂肪酸合酶抑制剂（奥利司他）的分布，作为缓解小鼠实体艾氏癌诱导的肝损伤的一种有前景的方法。
Pharmaceuticals (Basel). 2024 Jan 10;17(1):96. doi: 10.3390/ph17010096.
本文引用的文献
1
Design of Nanoparticles as Drug Carriers for Cancer Therapy.用于癌症治疗的纳米颗粒作为药物载体的设计
Cancer Genomics Proteomics. 2006 May-Aug;3(3-4):147-157. Epub 2006 Jan 1.
2
Toxicology and clinical potential of nanoparticles.纳米颗粒的毒理学与临床潜力
Nano Today. 2011 Dec;6(6):585-607. doi: 10.1016/j.nantod.2011.10.001.
3
Galactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects.半乳糖化壳聚糖/5-氟尿嘧啶纳米粒抑制小鼠肝癌生长及其副作用。
World J Gastroenterol. 2012 Nov 14;18(42):6076-87. doi: 10.3748/wjg.v18.i42.6076.
4
Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro.体外超声靶向微泡破坏介导 hVEGF-siRNA 转染的可生物降解纳米粒靶向递送至人 PC-3 细胞。
Int J Mol Med. 2013 Jan;31(1):163-71. doi: 10.3892/ijmm.2012.1175. Epub 2012 Nov 8.
5
5-Fluorouracil nanoparticles inhibit hepatocellular carcinoma via activation of the p53 pathway in the orthotopic transplant mouse model.氟尿嘧啶纳米粒通过在原位移植小鼠模型中激活 p53 通路抑制肝癌。
PLoS One. 2012;7(10):e47115. doi: 10.1371/journal.pone.0047115. Epub 2012 Oct 15.
6
Toxicological aspects for nanomaterial in humans.纳米材料对人体的毒理学方面。
Methods Mol Biol. 2013;948:1-12. doi: 10.1007/978-1-62703-140-0_1.
7
Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma.低分子量壳聚糖/血管内皮生长因子短发夹 RNA 治疗肝细胞癌。
Life Sci. 2012 Dec 10;91(23-24):1207-15. doi: 10.1016/j.lfs.2012.09.015. Epub 2012 Oct 5.
8
Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats.口服给予大鼠载姜黄素的 PLGA 和 PLGA-PEG 共混纳米粒后的药代动力学。
Colloids Surf B Biointerfaces. 2013 Jan 1;101:353-60. doi: 10.1016/j.colsurfb.2012.06.024. Epub 2012 Jun 28.
9
Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells.载吉西他滨纳米平台在耐药胰腺癌细胞中的作用机制研究。
BMC Cancer. 2012 Sep 22;12:419. doi: 10.1186/1471-2407-12-419.
10
Synthesis and characterization of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles as a sustained-release anticancer drug delivery system.载多柔比星聚乳酸-共-羟基乙酸纳米粒的合成与表征及其作为一种可持续释放的抗癌药物传递系统。
Appl Biochem Biotechnol. 2012 Nov;168(6):1434-47. doi: 10.1007/s12010-012-9868-4. Epub 2012 Sep 14.
Zotero 插件