皮质类固醇会增加大鼠肝脏微粒体的超氧阴离子生成量。
Corticosteroids increase superoxide anion production by rat liver microsomes.
作者信息
Nelson D H, Ruhmann-Wennhold A
出版信息
J Clin Invest. 1975 Oct;56(4):1062-5. doi: 10.1172/JCI108153.
Abstract
Superoxide anion production by liver microsomes from intact, adrenalectomized, and cortisoltreated adrenalectomized rats has been determined. The amount formed was roughly proportionate to the amount of cortisol given, and a similar response was seen in the activity of NADPH-cytochrome c reductase. The amount of measurable superoxide anion was markedly reduced by the addition of superoxide dismutase. The increased production of this potent free radical with cortisol therapy suggests that its formation may contribute to some of the harmful effects of corticosteroids given in more than physiologic amounts.
摘要
已测定了完整大鼠、肾上腺切除大鼠以及用皮质醇处理的肾上腺切除大鼠肝脏微粒体中超氧阴离子的产生情况。所形成的超氧阴离子量大致与给予的皮质醇量成比例，并且在NADPH - 细胞色素c还原酶的活性方面也观察到了类似的反应。添加超氧化物歧化酶后，可测量的超氧阴离子量显著减少。皮质醇治疗使这种强效自由基的产生增加，这表明其形成可能导致了超出生理剂量给予的皮质类固醇的一些有害作用。
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