Lerret Stacee, Mavis Alisha, Biank Vincent, Telega Grzegorz
Medical College of Wisconsin, Milwaukee, WI, USA.
Prog Transplant. 2013 Sep;23(3):253-7. doi: 10.7182/pit2013446.
Respiratory syncytial virus (RSV) is a ubiquitous virus responsible for acute infections of the respiratory tract in patients of all ages. RSV presents significant health risks to immunocompromised patients. Two patients, 1 before a liver transplant and 1 after a liver transplant, died of a severe RSV infection. Because of the high risk of death, we recommend expanding the criteria for palivizumab prophylaxis to 2 types of patients: (1) patients with chronic liver disease or who have received a liver transplant and are 24 months old or less and (2) transplant recipients with underlying pulmonary conditions who are less than 36 months old. Further research is indicated in pediatric solid-organ transplant centers to evaluate the effective management of RSV infection to prevent morbidity.
呼吸道合胞病毒（RSV）是一种普遍存在的病毒，可导致各年龄段患者发生急性呼吸道感染。RSV对免疫功能低下的患者构成重大健康风险。两名患者，1例在肝移植前，1例在肝移植后，死于严重的RSV感染。由于死亡风险高，我们建议将帕利珠单抗预防标准扩大到两类患者：（1）患有慢性肝病或接受过肝移植且年龄在24个月及以下的患者，以及（2）年龄小于36个月且患有基础肺部疾病的移植受者。儿科实体器官移植中心需要进行进一步研究，以评估RSV感染的有效管理措施，预防发病。
