Hill James, Preminger Tamar
Department of Pediatric Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio.
Catheter Cardiovasc Interv. 2014 Jul 1;84(1):110-3. doi: 10.1002/ccd.25183. Epub 2014 Apr 5.
Patent foramen ovale (PFO) is a known risk factor for paradoxical embolus, especially in the presence of other risk factors such as hypercoagulable states or central lines. A PFO is a common incidental finding in infants and children. However, paradoxical emboli are not common in infants, and so PFO closure is rarely indicated in this age group. We present two cases of PFO closures in identical 8 kg twin boys with Hurler's syndrome who had central lines for planned bone marrow transplants, with embolic stroke in one. We discuss the treatment options as well as the specific challenges based on the patients' age, size, and diagnoses. We also discuss the technical aspects and safety of percutaneous PFO closure.
卵圆孔未闭（PFO）是反常栓塞的已知危险因素，尤其是在存在其他危险因素（如高凝状态或中心静脉导管）的情况下。PFO在婴儿和儿童中是常见的偶然发现。然而，反常栓塞在婴儿中并不常见，因此在这个年龄组中很少需要进行PFO封堵。我们报告了两例患有黏多糖贮积症I型（Hurler综合征）的8公斤重同卵双胞胎男孩接受PFO封堵的病例，他们因计划进行骨髓移植而置入了中心静脉导管，其中一人发生了栓塞性中风。我们讨论了基于患者年龄、体型和诊断的治疗选择以及具体挑战。我们还讨论了经皮PFO封堵的技术方面和安全性。
