Arita Shinji, Arita Noboru, Hikasa Yoshiaki
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Japan.
Can Vet J. 2013 Mar;54(3):255-61.
This was a pilot study to determine the effectiveness of low-dose imatinib therapy for hemodynamic disturbances, including pulmonary arterial hypertension (PAH), and clinical manifestations caused by chronic heart failure in dogs. Six client-owned dogs with PAH were administered imatinib mesylate orally, 3 mg/kg body weight q24h, for 30 d. Physical examination, blood biochemical tests, radiography, and Doppler echocardiography were performed prior to imatinib administration and again 30 days after administration. Clinical scores were significantly reduced after imatinib treatment. Systolic pulmonary arterial pressure, heart rate, maximum tricuspid regurgitation velocity, left atrium/aorta ratio, right and left ventricular Tei indexes, early diastolic transmitral flow wave/mitral annulus velocity ratio, and plasma atrial natriuretic peptide concentration decreased significantly after therapy. Diastolic blood pressure, stroke volume, cardiac output, and left ventricular fractional shortening increased significantly after therapy. These results indicate that low-dose imatinib therapy was effective for heart failure in dogs with PAH.
这是一项初步研究，旨在确定低剂量伊马替尼治疗对犬类血流动力学紊乱（包括肺动脉高压（PAH））以及慢性心力衰竭所致临床表现的有效性。六只患有PAH的客户拥有犬口服甲磺酸伊马替尼，剂量为3mg/kg体重，每24小时一次，持续30天。在给予伊马替尼之前以及给药30天后再次进行体格检查、血液生化检测、放射照相和多普勒超声心动图检查。伊马替尼治疗后临床评分显著降低。治疗后，收缩期肺动脉压、心率、最大三尖瓣反流速度、左心房/主动脉比值、左右心室Tei指数、舒张早期二尖瓣血流波/二尖瓣环速度比值以及血浆心钠素浓度显著下降。治疗后舒张压、每搏输出量、心输出量和左心室缩短分数显著增加。这些结果表明，低剂量伊马替尼治疗对患有PAH的犬类心力衰竭有效。
