Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Basic Med Sci. 2013 Jul;16(7):873-81.
Objective(s) : It has been suggested that the efficiency of dry poder inhaler (DPI) is generally low. Therefore, the aim of the present research work was to use the solvent treatment of the carrier in DPIformulations to see the possibility of inducing desirable characteristics.
Lactose sieve fractions of 63-90 µm were submerged in ethanol or 80% v/v ethanol, methanol or propanol. Lactose crystals were then blended with either 1% w/w or 4% w/w salbutamol sulphate using a Turbula mixer. Drug detachment was studied using a multistage liquid. Laser particle size analyzer, DSC, and pycnometer were used to characterize the treated lactose and mannitol samples. SEM was used to study surface morphologies. In case of mannitol as a carrier only ethanol was used as a solvent.
SEM images displayed less rugosities and increased surface smoothness after submersion. Although the tomahawk like shape remained fairly constant in most lactose samples, the solvent treatment changed the shape of mannitol particles which was proved by SEM results. Deposition results showed that the type of solvent had an influence on fine particle fraction. In addition, the payload had also a big impact on fine particle fraction values. Generally, treated samples showed better performance compared to untreated samples. Solid state analysis by DSC showed that no major changes occurred in the treated samples compared to untreated samples.
The solvent treated method can be used as an approach to improve the performance of carriers such as lactose and mannitol in dry powder inhaler.
有人认为干粉吸入器（DPI）的效率通常较低。因此，本研究工作的目的是使用 DPI 制剂中载体的溶剂处理来观察诱导所需特性的可能性。
将 63-90 µm 的乳糖筛分级分浸入乙醇或 80% v/v 乙醇、甲醇或丙醇中。然后，将乳糖晶体与 1% w/w 或 4% w/w 的硫酸沙丁胺醇混合使用 Turbula 混合器。使用多阶段液体。激光粒度分析仪、DSC 和比重瓶研究药物脱落情况，用于对处理过的乳糖和甘露醇样品进行特征描述。SEM 用于研究表面形态。对于甘露醇作为载体，仅使用乙醇作为溶剂。
SEM 图像显示浸泡后粗糙度降低，表面光滑度增加。尽管大多数乳糖样品中的战斧状形状基本保持不变，但 SEM 结果表明溶剂处理改变了甘露醇颗粒的形状。沉积结果表明，溶剂的类型对细颗粒分数有影响。此外，有效载药量也对细颗粒分数值有很大影响。一般来说，与未处理的样品相比，处理过的样品表现出更好的性能。通过 DSC 的固态分析表明，与未处理的样品相比，处理过的样品没有发生重大变化。
溶剂处理方法可用于改善干粉吸入器中载体（如乳糖和甘露醇）的性能。
