Hlinák Z, Krejcí I
Research Institute for Pharmacy and Biochemistry, Prague.
Act Nerv Super (Praha). 1990 Jun;32(2):87-94.
Wistar female rats of two age groups were tested with the aim to investigate whether changes in spontaneous behaviour, habituation and sniffing responsiveness can be considered to be a function of age. Compared with young animals (2 months), aged animals (24 months) had lower locomotor and exploratory as well as investigatory scores but higher grooming and relaxation scores when exposed to a novel environment. Further, aged animals were inferior in habituation as characterized by decreased retention scores in investigatory and grooming patterns when exposed to the same environment for the second time. Finally, they exhibited both lower sniffing behaviour in the scent-free box and lower sniffing responsiveness to scent stimuli coming from the adult male rats. Thus, age-related behavioural changes repeatedly reported in learning and memory function were sufficiently complemented by the changes in natural behavioural repertoire. These behavioural patterns may serve as a model for the study of functional aspects of brain ageing as well as for search for geriatric drugs.
对两个年龄组的雌性Wistar大鼠进行了测试，目的是研究自发行为、习惯化和嗅觉反应性的变化是否可被视为年龄的函数。与年轻动物（2个月）相比，老年动物（24个月）在接触新环境时，运动、探索和探究得分较低，但梳理和放松得分较高。此外，老年动物在习惯化方面较差，表现为第二次接触相同环境时，探究和梳理模式的保持得分降低。最后，它们在无气味的盒子中表现出较低的嗅觉行为，对成年雄性大鼠发出的气味刺激的嗅觉反应性也较低。因此，学习和记忆功能中反复报道的与年龄相关的行为变化，被自然行为库中的变化充分补充。这些行为模式可作为研究大脑衰老功能方面以及寻找老年药物的模型。
