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癫痫持续状态时 NMDA 受体的转运：治疗意义。

Trafficking of NMDA receptors during status epilepticus: therapeutic implications.

机构信息

Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System-West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U.S.A.

出版信息

Epilepsia. 2013 Sep;54 Suppl 6(0 6):78-80. doi: 10.1111/epi.12285.

DOI:10.1111/epi.12285
PMID:24001081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4551407/
Abstract

We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.

摘要

我们使用两种癫痫持续状态（SE）模型来研究 N-甲基-D-天冬氨酸（NMDA）受体的运输。SE 与 NMDA 受体 NR1 亚基的表面表达增加有关，并且 NMDA 突触和 extrasynaptic 电流增加，表明齿状颗粒细胞上功能性 NMDA 受体数量增加。讨论了这些结果的治疗意义。

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本文引用的文献

1
Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus.快速的 NMDA 受体表面积累在癫痫持续状态下增加谷氨酸能兴奋。
Neurobiol Dis. 2013 Jun;54:225-38. doi: 10.1016/j.nbd.2012.12.015. Epub 2013 Jan 8.
2
Intramuscular versus intravenous therapy for prehospital status epilepticus.肌肉内与静脉内治疗院前癫痫持续状态。
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Rational polytherapy in the treatment of acute seizures and status epilepticus.急性发作和癫痫持续状态的合理联合治疗。
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Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity.在癫痫发生过程中，NMDA 受体位置异常导致兴奋性毒性。
Neurobiol Dis. 2011 Aug;43(2):507-15. doi: 10.1016/j.nbd.2011.04.024. Epub 2011 May 6.
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Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.γ-氨基丁酸A型（GABA(A)）受体的转运、抑制作用丧失与癫痫持续状态下耐药性的机制
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Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators.自我维持性癫痫持续状态：一种由谷氨酸受体增强以及P物质和其他肽类神经调节剂的可塑性变化所维持的病症。
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Felbamate in experimental model of status epilepticus.非氨酯在癫痫持续状态实验模型中的应用
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N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat.N-甲基-D-天冬氨酸受体拮抗剂可消除大鼠自我维持性癫痫持续状态的维持期。
Neurosci Lett. 1999 Apr 23;265(3):187-90. doi: 10.1016/s0304-3940(99)00238-4.
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Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus.在持续性癫痫持续状态过程中抗癫痫药物疗效随时间的下降。
Brain Res. 1998 Dec 14;814(1-2):179-85. doi: 10.1016/s0006-8993(98)01080-4.
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