癫痫持续状态时 NMDA 受体的转运：治疗意义。
Trafficking of NMDA receptors during status epilepticus: therapeutic implications.
机构信息
Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System-West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U.S.A.
出版信息
Epilepsia. 2013 Sep;54 Suppl 6(0 6):78-80. doi: 10.1111/epi.12285.
Abstract
We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.
摘要
我们使用两种癫痫持续状态（SE）模型来研究 N-甲基-D-天冬氨酸（NMDA）受体的运输。SE 与 NMDA 受体 NR1 亚基的表面表达增加有关，并且 NMDA 突触和 extrasynaptic 电流增加，表明齿状颗粒细胞上功能性 NMDA 受体数量增加。讨论了这些结果的治疗意义。
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2
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N Engl J Med. 2012 Feb 16;366(7):591-600. doi: 10.1056/NEJMoa1107494.
3
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4
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Neurobiol Dis. 2011 Aug;43(2):507-15. doi: 10.1016/j.nbd.2011.04.024. Epub 2011 May 6.
5
Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.γ-氨基丁酸A型（GABA(A)）受体的转运、抑制作用丧失与癫痫持续状态下耐药性的机制
J Neurosci. 2005 Aug 24;25(34):7724-33. doi: 10.1523/JNEUROSCI.4944-04.2005.
6
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Epilepsia. 2000;41 Suppl 6:S134-43. doi: 10.1111/j.1528-1157.2000.tb01572.x.
7
Felbamate in experimental model of status epilepticus.非氨酯在癫痫持续状态实验模型中的应用
Epilepsia. 2000 Feb;41(2):123-7. doi: 10.1111/j.1528-1157.2000.tb00130.x.
8
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9
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