厕所使用与沙眼的关联：一项随机临床试验的二次队列分析。
The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial.
机构信息
Francis I. Proctor Foundation, University of California, San Francisco, California; The Carter Center, Addis Ababa, Ethiopia; Departments of Ophthalmology and Epidemiology and Biostatistics, University of California, San Francisco, California; The Carter Center, Atlanta, Georgia; Institute for Global Health, University of California, San Francisco, California.
出版信息
Am J Trop Med Hyg. 2013 Oct;89(4):717-20. doi: 10.4269/ajtmh.13-0299. Epub 2013 Sep 3.
Abstract
Latrine use has been promoted as a component of an integrated strategy for trachoma control. As part of a randomized trial in Ethiopia, 12 communities received a mass azithromycin distribution followed by a latrine promotion intervention. A random sample of children ages 0-9 years in each community was monitored longitudinally for ocular chlamydia. After latrine construction ended, those communities with a higher proportion of households using latrines were more likely to experience a reduction in the prevalence of ocular chlamydia. Specifically, for each 10% increase in latrine use, there was a 2.0% decrease (95% confidence interval = 0.2-3.9% decrease) in the community prevalence of ocular chlamydia over the subsequent year (P = 0.04).
摘要
厕所的使用已被推广为沙眼综合防治策略的一个组成部分。在埃塞俄比亚的一项随机试验中，12 个社区接受了大规模阿奇霉素分发，随后开展了厕所推广干预。每个社区的 0-9 岁儿童随机样本进行了沙眼衣原体的纵向监测。在厕所建造结束后，那些有更高比例家庭使用厕所的社区更有可能降低眼部衣原体的患病率。具体来说，在接下来的一年里，每增加 10%的厕所使用率，社区中眼部沙眼衣原体的患病率就会降低 2.0%（95%置信区间为 0.2-3.9%的降低）（P = 0.04）。
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本文引用的文献
1
Evaluation of community intervention with pit latrines for trachoma control in Ghana, Mali, Niger and Nigeria.
Int Health. 2009 Dec;1(2):154-62. doi: 10.1016/j.inhe.2009.08.001.
2
Comparison of annual versus twice-yearly mass azithromycin treatment for hyperendemic trachoma in Ethiopia: a cluster-randomised trial.
Lancet. 2012 Jan 14;379(9811):143-51. doi: 10.1016/S0140-6736(11)61515-8. Epub 2011 Dec 20.
3
Diagnostic characteristics of tests for ocular Chlamydia after mass azithromycin distributions.
Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):235-40. doi: 10.1167/iovs.11-8493.
4
Efficacy of latrine promotion on emergence of infection with ocular Chlamydia trachomatis after mass antibiotic treatment: a cluster-randomized trial.
Int Health. 2011 Jun;3(2):75-84. doi: 10.1016/j.inhe.2011.03.004.
5
Slow resolution of clinically active trachoma following successful mass antibiotic treatments.
Arch Ophthalmol. 2011 Apr;129(4):512-3. doi: 10.1001/archophthalmol.2011.46.
6
Assessment of herd protection against trachoma due to repeated mass antibiotic distributions: a cluster-randomised trial.
Lancet. 2009 Mar 28;373(9669):1111-8. doi: 10.1016/S0140-6736(09)60323-8.
7
Evaluation of three years of the SAFE strategy (Surgery, Antibiotics, Facial cleanliness and Environmental improvement) for trachoma control in five districts of Ethiopia hyperendemic for trachoma.
Trans R Soc Trop Med Hyg. 2009 Oct;103(10):1001-10. doi: 10.1016/j.trstmh.2008.11.023. Epub 2009 Jan 28.
8
Associations between active trachoma and community intervention with Antibiotics, Facial cleanliness, and Environmental improvement (A,F,E).
PLoS Negl Trop Dis. 2008 Apr 30;2(4):e229. doi: 10.1371/journal.pntd.0000229.
9
Risk factors for active trachoma in children and trichiasis in adults: a household survey in Amhara Regional State, Ethiopia.
Trans R Soc Trop Med Hyg. 2008 May;102(5):432-8. doi: 10.1016/j.trstmh.2008.02.014. Epub 2008 Apr 3.
10
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