[The connection of polymorphism I/D of the gene angiotensin-converting ferment and D442G gene of protein-carrier of cholesterol ethers with atherosclerosis risk factors in patients of elderly and senile age with coronary heart disease in the Republic Sakha (Yakutia)].

The authors analyse allocation of genotypes frequencies of polymorphism I/D of the gene of angiotensin-converting ferment (ASYA) and D442G gene of protein-transmitting agent of cholesterol ethers (CETP) in patients of elderly, senile age and long-livers with coronary heart disease taking into account their nationality, age and sex. With the age, the frequency reduction of occurrence of genotype ACE*I/I has been observed and there is a tendency to increase of genotype frequency ACED/D. Sexual distinctions in frequency of revealing of homozygous genotype ACED/D have been revealed at the relative analysis of genotypes ACED/D and ACED/I. The carriers of genotype ACED/D significantly more are males than females. In the general group (especially in the group of Yakuts), the carriers of genotype ACEI/I have demonstrated significantly more often the hypertrophy of myocardium of the left ventricle, which is accurately reflected with the help of ECG sign of Sokolov-Lion. While studying the polymorphism D442G of the gene CETP, the carriers of genotype CETP:D/G are significantly more often met among Yakuts, than non-indigenous population. The comparison of genotypes frequencies I/D-polymorphism of the gene ACE have showed reliable distinctions of BBI, indexes of blood lipids. The comparison of genotypes CETPD/D, CETPD/*G has not yielded authentic connection with risk factors of coronary heart disease.