翻译：迷失在翻译中：内质网应激与糖尿病β细胞健康的衰退。
Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus.
机构信息
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Diabetes Obes Metab. 2013 Sep;15 Suppl 3(0 3):159-69. doi: 10.1111/dom.12163.
Abstract
Emerging data illustrate a pivotal role for activation of β-cell endoplasmic reticulum (ER) stress pathways in diabetes pathophysiology. The purpose of this review is to appraise the evidence for β-cell ER stress in human type 1 and 2 diabetes, review the molecular signalling pathways involved in the unfolded protein response and ER stress signalling, and to provide data from polyribosome profiling to illustrate the impact of ER stress on the mRNA translation response. Finally, we will discuss existing and novel therapeutic strategies that target β-cell ER stress and discuss their use in rodent and human type 1 and 2 diabetes.
摘要
新兴数据表明，β 细胞内质网（ER）应激途径的激活在糖尿病发病机制中起着关键作用。本文的目的是评估人 1 型和 2 型糖尿病中β 细胞 ER 应激的证据，综述涉及未折叠蛋白反应和 ER 应激信号的分子信号通路，并提供多核糖体谱分析的数据来说明 ER 应激对 mRNA 翻译反应的影响。最后，我们将讨论现有的和新的针对β细胞 ER 应激的治疗策略，并讨论它们在啮齿动物和人 1 型和 2 型糖尿病中的应用。
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