Dermathology Department "Maggiore della Carità" Hospital, Novara, Italy -
G Ital Dermatol Venereol. 2013 Oct;148(5):443-51.
The aim of this study was to review our experience with regards to patients with cutaneous melanoma diagnosed from 1983 to 2009, followed-up in our Dermatological Department of Novara.
A retrospective study of 762 patients diagnosed with cutaneous melanoma in the Dermatological Department of Novara between 1983 and 2009 was conducted. Information was extracted from our melanoma patient database. The database included demographical, clinical and pathological variables of the patient. Clinical and pathological factors predicting survival were analyzed using the Kaplan-Meier curves and the Log-Rank Test (univariate analysis).
Staging (American Joint Committee on Cancer 2001) of patients (P=0.000), Breslow thickness (P=0.000), primary ulceration and regression of the lesion (P=0.000), type of first (P<0.039) and second recurrence (P<0.011) were strongly correlated with overall and disease free survival. Sentinel lymph node biopsy was not correlated with disease free survival (P=0.153), it influences only overall survival (P=0.007) CONCLUSION: Our results confirms that sentinel node biopsy, Breslow thickness, ulceration, regression, staging, first and second recurrence are important variable for overall survival and disease free survival, sentinel lymph node status influence only overall survival instead.
本研究旨在回顾我们在诺瓦拉皮肤科对 1983 年至 2009 年期间诊断为皮肤黑色素瘤的患者的诊治经验。
对 1983 年至 2009 年期间在诺瓦拉皮肤科诊断为皮肤黑色素瘤的 762 例患者进行回顾性研究。从我们的黑色素瘤患者数据库中提取信息。该数据库包括患者的人口统计学、临床和病理变量。采用 Kaplan-Meier 曲线和 Log-Rank 检验（单因素分析）分析预测生存的临床和病理因素。
分期（美国癌症联合委员会 2001 年）（P=0.000）、Breslow 厚度（P=0.000）、原发溃疡和病变消退（P=0.000）、首次（P<0.039）和第二次复发（P<0.011）的类型与总生存和无病生存密切相关。前哨淋巴结活检与无病生存无关（P=0.153），仅影响总生存（P=0.007）。
我们的结果证实，前哨淋巴结活检、Breslow 厚度、溃疡、消退、分期、首次和第二次复发是总生存和无病生存的重要变量，前哨淋巴结状态仅影响总生存。
