Radulović D, Pećanac D, Zivanović L, Agatonović-Kustrin S
Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Farmaco. 1990 Apr;45(4):447-53.
A spectrophotometric determination of oxprenolol hydrochloride in pharmaceutical preparations is described. The method is based on the reaction of oxprenolol hydrochloride with Fe (III) ion in the presence of ammonium thiocyanate, in acid media. The complex formed between oxprenolol hydrochloride and Fe (III) ion was extracted with chloroform and assayed spectrophometrically at 477 nm. The results obtained are reproducible and hence the method is suitable for the determination of oxprenolol hydrochloride in pharmaceutical dosage forms.
本文描述了一种分光光度法测定药物制剂中盐酸氧烯洛尔的方法。该方法基于在酸性介质中，盐酸氧烯洛尔与硫氰酸铵存在下的铁（III）离子反应。盐酸氧烯洛尔与铁（III）离子形成的络合物用氯仿萃取，并在477nm处进行分光光度测定。所得结果具有重现性，因此该方法适用于药物剂型中盐酸氧烯洛尔的测定。
