NR4A 核受体在免疫和动脉粥样硬化中的作用。
NR4A nuclear receptors in immunity and atherosclerosis.
机构信息
Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, the Netherlands.
出版信息
Curr Opin Lipidol. 2013 Oct;24(5):381-5. doi: 10.1097/MOL.0b013e3283643eac.
Abstract
PURPOSE OF REVIEW
To understand chronic inflammatory diseases such as atherosclerosis, we require in-depth knowledge on immune-cell differentiation, function of specific immune-cell subsets and endothelial cell-mediated extravasation. In this review, we summarize a number of very recent observations on the pivotal function of NR4A nuclear receptors in immunity and atherosclerosis.
RECENT FINDINGS
NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation.
SUMMARY
These exciting, novel insights on the function of NR4A nuclear receptors in immunity, vascular cells and atherosclerosis will initiate a plethora of studies to understand the underlying molecular mechanisms, which will culminate in the identification of novel NR4A targets to modulate chronic inflammatory disease.
摘要
目的综述
为了了解动脉粥样硬化等慢性炎症性疾病，我们需要深入了解免疫细胞分化、特定免疫细胞亚群的功能以及内皮细胞介导的血管外渗。在这篇综述中，我们总结了一些关于 NR4A 核受体在免疫和动脉粥样硬化中的关键作用的最新观察结果。
最近的发现
NR4A 核受体参与了胸腺细胞的阴性选择、Treg 分化和 Ly6C 单核细胞的发育。Nur77 和 Nurr1 可减轻小鼠的动脉粥样硬化，而 NOR-1 则加重血管损伤形成。
总结
这些关于 NR4A 核受体在免疫、血管细胞和动脉粥样硬化中的功能的令人兴奋的新见解将引发大量研究，以了解潜在的分子机制，最终确定调节慢性炎症性疾病的新的 NR4A 靶点。
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