Kriukov A I, Frantsuzov V N, Smirnova N A, Agafonov A A
Vestn Otorinolaringol. 2013(4):40-3.
The objective of the present study was to develop the algorithm for early clinical, laboratory, and instrumental diagnostics of sepsis in the patients presenting with pyo-inflammatory ENT diseases. The study included 50 patients with pyo-inflammatory ENT diseases complicated by generalization of infection. The scheme (algorithm) developed for their examination allowed to diagnose sepsis at the early stages of hospitalization in the patients presenting with pyo-inflammatory ENT pathology. The diagnostic algorithm included the criteria for syndrome of systemic inflammatory reaction (SSIR), the Kalf-Kalif leukocytic intoxication index (LII), the procalcitonin test (PKT), the integral severity of illness scale (APACHE-II) and the organ failure assessment score (SOFA). Timely preoperative diagnostics of septic complications and sanation of the primary infection site in the combination with early intensive therapy under conditions of a resuscitation department made it possible to avoid further progress of generalization of the infection and thereby to reduce the number of secondary interventions, to improve prognosis of the disease, and lower the mortality rate down to 12% in the study group (compared with 44% in the control one).
本研究的目的是开发用于对患有脓性炎症性耳鼻喉疾病的患者进行败血症早期临床、实验室及仪器诊断的算法。该研究纳入了50例因感染扩散而并发脓性炎症性耳鼻喉疾病的患者。为他们制定的检查方案（算法）能够在患有脓性炎症性耳鼻喉疾病的患者住院早期诊断败血症。诊断算法包括全身炎症反应综合征（SSIR）标准、卡尔夫 - 卡里夫白细胞中毒指数（LII）、降钙素原检测（PKT）、疾病严重程度积分量表（APACHE-II）以及器官功能衰竭评估评分（SOFA）。在复苏科室的条件下，及时对败血症并发症进行术前诊断和对原发性感染部位进行清理，再结合早期强化治疗，使得避免感染进一步扩散成为可能，从而减少二次干预的次数，改善疾病预后，并将研究组的死亡率降至12%（对照组为44%）。
