Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
Chem Commun (Camb). 2013 Oct 21;49(82):9422-4. doi: 10.1039/c3cc45139a.
The first organocatalytic asymmetric sequential allylic alkylation-cyclization of Morita-Baylis-Hillman carbonates and 3-hydroxyoxindoles has been developed to afford spirooxindoles bearing α-methylene-γ-butyrolactone motifs in 25-85% yield, 60-94% ee and up to >20 : 1 diastereoselectivity.
已开发出首例有机催化不对称顺序烯丙基烷基化-环化 Morita-Baylis-Hillman 碳酸酯和 3-羟基氧杂吲哚，以提供螺[吲哚啉-3,3′-吡咯烷]-2,5′-二酮骨架，收率为 25-85%，ee 值为 60-94%，非对映选择性高达>20 : 1。
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