基于Morita-Baylis-Hillman碳酸酯的有机催化氧化吲哚不对称烯丙基烷基化反应。
Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates.
作者信息
Jiang Kun, Peng Jing, Cui Hai-Lei, Chen Ying-Chun
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
出版信息
Chem Commun (Camb). 2009 Jul 14(26):3955-7. doi: 10.1039/b905177e. Epub 2009 May 29.
DOI:10.1039/b905177e
PMID:19662264
Abstract
The organic Lewis base-catalysed asymmetric allylic alkylation of 3-substituted oxindoles with Morita-Baylis-Hillman carbonates is reported, affording multifunctional oxindoles with adjacent quaternary and tertiary chiral centres (dr up to 92 : 8, 86-97% ee).
摘要
报道了有机路易斯碱催化3-取代氧化吲哚与森田-贝利斯-希尔曼碳酸酯的不对称烯丙基烷基化反应，得到具有相邻季碳和叔碳手性中心的多功能氧化吲哚（非对映选择性高达92:8，对映体过量为86-97%）。
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