重组丝氨酸蛋白酶抑制剂B的N端变体：对木瓜蛋白酶和组织蛋白酶B亲和力的影响 - Suppr

Suppr

超能文献

N-terminal variants of recombinant stefin B: effect on affinity for papain and cathepsin B.

作者信息

Thiele U, Assfalg-Machleidt I, Machleidt W, Auerswald E A

机构信息

Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie, Universität München, FRG.

出版信息

Biol Chem Hoppe Seyler. 1990 May;371 Suppl:125-36.

PMID:2400573

Abstract

摘要

相似文献

N-terminal variants of recombinant stefin B: effect on affinity for papain and cathepsin B.重组丝氨酸蛋白酶抑制剂B的N端变体：对木瓜蛋白酶和组织蛋白酶B亲和力的影响

Biol Chem Hoppe Seyler. 1990 May;371 Suppl:125-36.

Grafting of features of cystatins C or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances inhibition of cysteine proteinases.将胱抑素C或B的特征嫁接到胱抑素A（抑半胱氨酸蛋白酶蛋白A）的N端区域或第二个结合环中，可显著增强对半胱氨酸蛋白酶的抑制作用。

Biochemistry. 2003 Sep 30;42(38):11326-33. doi: 10.1021/bi030119v.

Molecular mechanism of inhibition of cysteine proteinases by their protein inhibitors: kinetic studies with natural and recombinant variants of cystatins and stefins.半胱氨酸蛋白酶的蛋白质抑制剂对其抑制作用的分子机制：胱抑素和丝抑素天然及重组变体的动力学研究

Biomed Biochim Acta. 1991;50(4-6):613-20.

Molecular cloning, sequencing, expression of Chinese sturgeon cystatin in yeast Pichia pastoris and its proteinase inhibitory activity.中华鲟半胱氨酸蛋白酶抑制剂在毕赤酵母中的分子克隆、测序、表达及其蛋白酶抑制活性

J Biotechnol. 2006 Sep 1;125(2):231-41. doi: 10.1016/j.jbiotec.2006.02.023. Epub 2006 May 18.

Recombinant Q53E- and Q53N--chicken egg white cystatin variants inhibit papain, actinidin and cathepsin B.重组Q53E和Q53N——鸡卵清半胱氨酸蛋白酶抑制剂变体可抑制木瓜蛋白酶、猕猴桃蛋白酶和组织蛋白酶B。

Biomed Biochim Acta. 1991;50(4-6):621-5.

Cystatins as calpain inhibitors: engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of mu-calpain.半胱氨酸蛋白酶抑制剂作为钙蛋白酶抑制剂：工程化鸡半胱氨酸蛋白酶抑制剂和丝抑蛋白B激肽原结构域2杂种支持与μ-钙蛋白酶催化亚基的半胱氨酸蛋白酶抑制剂样相互作用模式。

Biol Chem. 2001 Jan;382(1):97-107. doi: 10.1515/BC.2001.015.

Deletion of the carboxy terminal part of stefin B does not have a major effect for binding to papain.删除stefin B的羧基末端部分对其与木瓜蛋白酶的结合没有重大影响。

Biomed Biochim Acta. 1991;50(4-6):627-9.

The contribution of N-terminal region residues of cystatin A (stefin A) to the affinity and kinetics of inhibition of papain, cathepsin B, and cathepsin L.胱抑素A（丝抑素A）N端区域残基对木瓜蛋白酶、组织蛋白酶B和组织蛋白酶L抑制作用的亲和力及动力学的贡献。

Biochemistry. 1999 Jun 1;38(22):7339-45. doi: 10.1021/bi990003s.

Importance of the second binding loop and the C-terminal end of cystatin B (stefin B) for inhibition of cysteine proteinases.胱抑素B（抑半胱氨酸蛋白酶蛋白B）的第二个结合环和C末端对抑制半胱氨酸蛋白酶的重要性。

Biochemistry. 1999 Aug 10;38(32):10519-26. doi: 10.1021/bi990488k.

Importance of the evolutionarily conserved glycine residue in the N-terminal region of human cystatin C (Gly-11) for cysteine endopeptidase inhibition.人胱抑素C N端区域（甘氨酸-11）中进化保守的甘氨酸残基对半胱氨酸内肽酶抑制作用的重要性。

Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):123-9. doi: 10.1042/bj2910123.

引用本文的文献

Steady-state and time-resolved fluorescence spectroscopic studies on interaction of the N-terminal region with the hairpin loop of the phytocystatin Scb.关于植物胱抑素Scb的N端区域与发夹环相互作用的稳态和时间分辨荧光光谱研究。

J Fluoresc. 2009 Jul;19(4):631-9. doi: 10.1007/s10895-008-0454-7. Epub 2008 Dec 23.

Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).鉴定胱抑素B基因中的突变，该基因是导致翁韦里希特-伦德伯格型进行性肌阵挛癫痫（EPM1）的原因。

Am J Hum Genet. 1997 Feb;60(2):342-51.

Studies on activation and inhibition of cathepsin B from buffalo liver.水牛肝脏组织中组织蛋白酶B的激活与抑制研究

J Protein Chem. 1996 Jan;15(1):87-93. doi: 10.1007/BF01886814.

Interaction between cystatin-derived peptides and papain.胱抑素衍生肽与木瓜蛋白酶之间的相互作用。

J Protein Chem. 1993 Feb;12(1):23-31. doi: 10.1007/BF01024910.

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.人肝脏组织半胱氨酸蛋白酶B的2.15埃X射线晶体结构精修：其特异性的结构基础

EMBO J. 1991 Sep;10(9):2321-30. doi: 10.1002/j.1460-2075.1991.tb07771.x.

Characterization by rapid-kinetic and equilibrium methods of the interaction between N-terminally truncated forms of chicken cystatin and the cysteine proteinases papain and actinidin.通过快速动力学和平衡方法对鸡半胱氨酸蛋白酶抑制剂N端截短形式与半胱氨酸蛋白酶木瓜蛋白酶和猕猴桃蛋白酶之间相互作用的表征。

Biochem J. 1992 Aug 15;286 ( Pt 1)(Pt 1):165-71. doi: 10.1042/bj2860165.

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