Blank N, Schönland S O
Universitätsklinikum Heidelberg, Medizinische Klinik 5, Sektion Rheumatologie und Amyloidosezentrum, Heidelberg.
Dtsch Med Wochenschr. 2013 Sep;138(37):1835-8. doi: 10.1055/s-0033-1349428. Epub 2013 Sep 4.
Systemic AA amyloidosis is a severe complication of chronic inflammatory diseases. Renal involvement is the predominant organ manifestation. Patients who are at risk for developing AA amyloidosis should be screened for microalbuminuria. The goal of therapy is an effective control of the acute phase reaction. A well controlled blood pressure and nephroprotective treatment contribute to the maintenance of renal function. In case of progressive amyloidosis dialysis is required. Renal transplantation can be performed if the underlying disease is well controlled.
系统性AA型淀粉样变性是慢性炎症性疾病的一种严重并发症。肾脏受累是主要的器官表现。有发生AA型淀粉样变性风险的患者应筛查微量白蛋白尿。治疗的目标是有效控制急性期反应。良好控制血压和进行肾脏保护治疗有助于维持肾功能。对于进行性淀粉样变性，需要进行透析。如果基础疾病得到良好控制，可以进行肾移植。
