Department of Neurology, Section Neuromuscular Disorders, F02.230, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Muscle Nerve. 2013 Dec;48(6):851-64. doi: 10.1002/mus.24070.
This first article of this review deals with neuroscientific aspects of immune-mediated demyelinating neuropathies. It describes the anatomy and physiology of normal myelinated axons, methods of studying peripheral nerve physiology, pathophysiological consequences of demyelination or damage at the node of Ranvier, and the mechanisms that may lead to impaired axonal membrane dysfunction or axonal degeneration. This article (part I) will be followed by a second (part II) dealing with clinical aspects of these neuropathies.
这篇综述的第一篇文章涉及免疫介导的脱髓鞘神经病的神经科学方面。它描述了正常有髓轴突的解剖和生理学、研究周围神经生理学的方法、Ranvier 结处脱髓鞘或损伤的病理生理后果，以及可能导致轴突膜功能障碍或轴突变性的机制。这篇文章（第一部分）之后将有第二篇（第二部分），讨论这些神经病的临床方面。
