Weissbach L, Ibach B
Klin Padiatr. 1975 Jul;187(4):289-300.
Undescended testis is of clinical importance because there are increased risks of milignancy and torsion and disturbances of fertility and psychosexual development. New quantitative morphologic investigations show that human prepubertal testicular maturation does not occur in phases but is continuous. This made it necessary to investigate afresh the causes of disturbance of fertility and the treatment of indescended testis. Our own investigations show that damage to the germ epithelium need not be congenital but may develop because of its ectopy. If, in dogs, a testis is placed into the abdomen, not only this but also the normally placed testis in the scrotum is damaged. The diameter of the tubules and their surfaces as well as the numbers of pachtenous primary spermatocytes are significantly reduced both in the displaced and the normally placed testis. Nuclear surfaces and density of the cells involved in spermatogenesis differ from those in the controls. The findings support the plea for early hormonal or surgical treatment in order to prevent later disturbances of fertility.
隐睾具有临床重要性，因为其恶变、扭转风险增加，且会干扰生育和心理性发育。新的定量形态学研究表明，人类青春期前睾丸成熟并非分阶段进行，而是持续的。这使得有必要重新研究生育障碍的原因以及隐睾的治疗方法。我们自己的研究表明，生殖上皮的损伤不一定是先天性的，而是可能因其异位而发生。如果在狗身上将一个睾丸置于腹腔内，不仅这个睾丸，而且阴囊内正常位置的睾丸也会受损。移位睾丸和正常位置睾丸的曲细精管直径及其表面积以及初级精母细胞的数量均显著减少。参与精子发生的细胞的核表面积和密度与对照组不同。这些发现支持尽早进行激素或手术治疗以预防后期生育障碍的主张。
