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[使用吸入性糖皮质激素治疗的哮喘患者胃黏膜的比较形态学]

[Comparative morphology of the gastric mucosa in asthmatic patients using inhaled glucocorticosteroid therapy].

作者信息

Mikhaleva L M, Barkhina T G, Shchegoleva N N, Gracheva N A, Golovanova V E

出版信息

Arkh Patol. 2013 Mar-Apr;75(2):9-15.

Abstract

The immunomorphological characteristics of the gastric mucosa were evaluated and analyzed in patients with asthma of varying severity who received or did not receive inhaled or oral glucocorticosteroid therapy and in the control group. Immunohistological examination and morphometric analysis were used to study inflammatory infiltration in fundic mucosal biopsy specimens from patients with and without asthma. There were crucial immunomorphological differences between the examined patient groups and signs of the gastroprotective effect of inhaled glucocorticosteroids used in the basic therapy of asthma on the gastric mucosa. There was evidence that it is urgent to prevent erosive and atrophic gastritis and other inflammatory stomach diseases in asthma.

摘要

对接受或未接受吸入或口服糖皮质激素治疗的不同严重程度哮喘患者以及对照组患者的胃黏膜免疫形态学特征进行了评估和分析。采用免疫组织学检查和形态计量分析方法,研究有无哮喘患者胃底黏膜活检标本中的炎症浸润情况。在所检查的患者组之间存在关键的免疫形态学差异,且哮喘基础治疗中使用的吸入性糖皮质激素对胃黏膜具有胃保护作用的迹象。有证据表明,预防哮喘患者的糜烂性和萎缩性胃炎及其他炎症性胃部疾病迫在眉睫。

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