对SSA/Ro抗原免疫反应的女性优势与新生儿红斑狼疮的风险
Female predominance of immune response to SSA/Ro antigens and risk of neonatal lupus erythematosus.
作者信息
Miyagawa S, Dohi K, Yoshioka A, Shirai T
机构信息
Department of Dermatology, Nara Medical University, Japan.
出版信息
Br J Dermatol. 1990 Aug;123(2):223-7. doi: 10.1111/j.1365-2133.1990.tb01850.x.
Abstract
Eight-hundred and twenty-five patients attending the hospital with clinical signs and symptoms of collagen diseases were tested for anti-SSA/Ro antibody. The frequency of positivity to SSA/Ro was significantly higher in females, 11.0%, than in males, 3.2% (P less than 0.01). Five babies born to anti-SSA/Ro positive mothers all had neonatal lupus erythematosus and in one there were various cardiac abnormalities.
摘要
825名因胶原病临床症状和体征前来医院就诊的患者接受了抗SSA/Ro抗体检测。抗SSA/Ro抗体阳性率在女性中显著高于男性，女性为11.0%，男性为3.2%（P<0.01）。5名抗SSA/Ro抗体阳性母亲所生的婴儿均患有新生儿红斑狼疮，其中1名婴儿存在多种心脏异常。
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