de Villiers W J, Louw J P, Strachan A F, Etsebeth S M, Shephard E G, de Beer F C
Department of Internal Medicine, University of Stellenbosch Medical School, Tygerberg, South Africa.
Br J Obstet Gynaecol. 1990 Aug;97(8):725-30. doi: 10.1111/j.1471-0528.1990.tb16247.x.
Serum levels of C-reactive protein (CRP) and amyloid A protein (SAA) were measured prospectively using immunoradiometric assays in normal pregnant women, newborn infants and women with prelabour rupture of membranes (PROM), focusing on the peripartum period. CRP levels in 50 healthy women at 38 weeks gestation did not differ significantly from previously established normal values. CRP levels in 67 healthy women sampled serially in labour from admission to 96 h postpartum confirm the physiological occurrence of a major acute phase response. The serial CRP levels of 16 women with PROM did not differ significantly from the wide range of CRP levels found in the normal postpartum period. This complicates the use of CRP as an early predictor of clinical chorio-amnionitis. Serial SAA levels in 17 women at 38 weeks gestation, immediately postpartum and 24 h postpartum showed a parallel rise to CRP in the peripartum period. Significant differences between maternal and neonatal CRP and SAA levels were demonstrated, implying a lack of transplacental transfer during labour.
在正常孕妇、新生儿以及胎膜早破（PROM）的女性中，前瞻性地使用免疫放射分析测定血清C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）水平，重点关注围产期。50名妊娠38周的健康女性的CRP水平与先前确定的正常数值无显著差异。67名从入院至产后96小时分娩过程中连续采样的健康女性的CRP水平证实了主要急性期反应的生理性发生。16名胎膜早破女性的连续CRP水平与正常产后期间发现的广泛CRP水平范围无显著差异。这使得CRP作为临床绒毛膜羊膜炎早期预测指标的应用变得复杂。17名妊娠38周、产后即刻和产后24小时的女性的连续SAA水平在围产期与CRP呈平行上升。母体和新生儿的CRP及SAA水平存在显著差异，这意味着分娩期间缺乏经胎盘转运。
