a Programa de Pós-graduação em Engenharia Química, Universidade Estadual de Maringá , Maringá , Brazil.
Nat Prod Res. 2013;27(24):2355-9. doi: 10.1080/14786419.2013.830215. Epub 2013 Sep 5.
The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.
采用超临界二氧化碳从梨果胡椒中提取的物质对酵母和丝状真菌的抗真菌活性进行了测试。最活跃的提取物是从 40°C 和 25 MPa 下的梨果胡椒叶提取物中获得的，对须癣毛癣菌的最小抑菌浓度为 3.9 μg/mL。所有提取物中均存在新木脂素 eupomatenoid-3、eupomatenoid-5、eupomatenoid-6 和 conocarpan。结果表明，可进一步研究利用超临界提取获得的梨果胡椒提取物，将其作为用于医学的生物活性化合物的潜在来源。
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