Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Muhimbili Research Centre, National Institute of Medical Research, Dar Es Salaam, Tanzania.
Epidemiol Infect. 2014 Jun;142(6):1334-42. doi: 10.1017/S0950268813002070. Epub 2013 Sep 6.
We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.
我们评估了结核病（TB）疾病和 HIV 感染对身体活动水平的影响。使用心率和运动传感器来评估结核病患者和非结核病对照者的习惯性身体活动。在多变量线性回归模型中，调整年龄、性别、血红蛋白和α-1-酸性糖蛋白（AGP）后，评估了痰阴性结核病、痰阳性结核病、HIV 和身体活动估计之间的关联。与对照组相比，痰阳性（eB 0·43，95%置信区间 0·29-0·64）和痰阴性（eB 0·67，95%置信区间 0·47-0·94）结核病以及 HIV 感染（eB 0·59，95%置信区间 0·46-0·75）与活动减少相关。贫血解释了 HIV 影响的很大一部分，而升高的 AGP 主要介导了结核病的影响。身体活动的水平受到结核病和 HIV 的高度影响，主要通过感染性贫血和相关的急性期反应来介导。
