Department of Public Health, Clinical and Molecular Medicine-Section of Psychiatry, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy.
Psychiatry Res. 2013 Dec 30;210(3):739-44. doi: 10.1016/j.psychres.2013.08.022. Epub 2013 Sep 3.
To date, few studies have reported analytical data relating to clinical remission, functional remission and subjective experience. The present study aimed to investigate these aspects in a sample of chronic outpatients.
112 schizophrenic or schizoaffective outpatients (Males=60; Females=52; mean age 43.5 ± 9.42 yr) were evaluated with regard to symptomatology (SCID-I; PANSS, CGI-SCH scales), functioning (PSP scale), subjective wellbeing (SWN-K scale) and Quality of Life (WHO-QoL-Bref scale).
50% of patients were found to be in remission. Significantly higher scores at PANNS, CGI-SCH, PSP, but not at SWN and WHO-QoL, were found among remitted patients; a relevant proportion of remitted subjects continued to manifest a moderate level of symptoms (score >3) both at PANSS (35% of cases) and CGI-SCH (29% of cases), significant functional impairment (total score <70) at PSP (68% of cases ), and a lesser degree of wellbeing (total score <80) at SWN-K (34% of cases).
patients in whom clinical remission was confirmed may display persisting symptoms, relevant areas of functional impairment and a decreased sense of wellbeing.
迄今为止，鲜有研究报告与临床缓解、功能缓解和主观体验相关的分析数据。本研究旨在调查慢性门诊患者样本中的这些方面。
对 112 名精神分裂症或分裂情感障碍门诊患者（男性=60；女性=52；平均年龄 43.5±9.42 岁）进行评估，评估内容包括症状（SCID-I；PANSS、CGI-SCH 量表）、功能（PSP 量表）、主观幸福感（SWN-K 量表）和生活质量（WHO-QoL-Bref 量表）。
50%的患者被发现处于缓解状态。在 PANNS、CGI-SCH、PSP 方面，缓解组的评分明显更高，但在 SWN 和 WHO-QoL 方面则不然；在 PANSS（35%的病例）和 CGI-SCH（29%的病例）方面，缓解组的大部分患者仍表现出中等程度的症状（评分>3），在 PSP（68%的病例）方面表现出显著的功能障碍（总分<70），在 SWN-K（34%的病例）方面表现出幸福感较低（总分<80）。
经临床确认缓解的患者可能会表现出持续的症状、严重的功能损害和幸福感降低。
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