Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gene. 2013 Nov 10;530(2):301-8. doi: 10.1016/j.gene.2013.08.043. Epub 2013 Sep 2.
Genetic polymorphisms of glutathione S-transferases (GSTs) and type 2 diabetes mellitus (T2DM) risk have been widely studied, however, the results were somewhat conflicting. To evaluate the association of GSTs (GSTM1, GSTT1 and GSTP1) gene polymorphisms with T2DM, a meta-analysis was performed before October, 2012. ORs were pooled according to random-effects model. There were a total of 1354/1666 (n=9) cases/controls (studies) for GSTM1, 1271/1470 (n=8) for GSTT1, and 1205/1250 (n=7) for GSTM1. There were significant associations between GSTM1 polymorphism, GSTT1 polymorphism and T2DM in the contrast of present genotype vs. null genotype, with pooled OR=1.99 (95%CI=1.46-2.71) and OR=1.61 (95%CI=1.19-2.17), respectively. Yet no significant association of GSTP1 polymorphism and T2DM was showed. When stratified by ethnicity, the significant associations were also existed in Asians for GSTM1 and GSTT1, but not GSTP1. No publication bias but some extent of heterogeneity was observed. Finally, the accumulated evidence proved the obvious associations of GSTM1 and GSTT1 polymorphisms with an increased risk of T2DM.
谷胱甘肽 S-转移酶（GSTs）的遗传多态性与 2 型糖尿病（T2DM）的风险已经被广泛研究，然而，结果有些相互矛盾。为了评估 GSTs（GSTM1、GSTT1 和 GSTP1）基因多态性与 T2DM 的相关性，我们在 2012 年 10 月之前进行了一项荟萃分析。根据随机效应模型汇总 OR 值。共有 1354/1666（n=9）例/对照（研究）用于 GSTM1，1271/1470（n=8）用于 GSTT1，1205/1250（n=7）用于 GSTM1。在现有基因型与缺失基因型的比较中，GSTM1 多态性、GSTT1 多态性与 T2DM 之间存在显著相关性，汇总 OR=1.99（95%CI=1.46-2.71）和 OR=1.61（95%CI=1.19-2.17）。然而，GSTP1 多态性与 T2DM 之间无显著相关性。按种族分层时，GSTM1 和 GSTT1 在亚洲人群中也存在显著相关性，但 GSTP1 则不然。未发现发表偏倚，但存在一定程度的异质性。最后，累积证据证明 GSTM1 和 GSTT1 多态性与 T2DM 风险增加明显相关。
