Goutzourelas Nikolaos, Orfanou Marina, Charizanis Ioannis, Leon George, Spandidos Demetrios A, Kouretas Demetrios
Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.
Eatwalk IKE, 15124 Athens, Greece.
Exp Ther Med. 2018 Aug;16(2):635-642. doi: 10.3892/etm.2018.6204. Epub 2018 May 23.
This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention. Dietary intervention resulted in weight loss, a reduction in BF% and a decrease in RQ. The GSH levels were significantly decreased following intervention, while the levels of TBARS and CARB were not affected. Based on the initial GSH levels, the patients were divided into 2 groups as follows: The high GSH group (GSH, >3.5 µmol/g Hb) and the low GSH group (GSH <3.5 µmol/g Hb). Greater weight and BF loss were observed in patients with high GSH levels. It was observed that patients with MetS and obesity with high GSH values responded better to the dietary therapy, exhibiting more significant changes in weight and BF%. This finding underscores the importance of identifying redox status markers, particularly GSH, in obese patients with MetS. Knowing the levels of GSH may aid in developing a better design of an individualized dietary plan for individuals who wish to lose weight.
本研究调查了氧化还原状态标志物在饮食干预和减肥运动前后对代谢综合征（MetS）和肥胖的影响。共有103名患有MetS和肥胖症的成年人参与了本研究，并遵循个性化饮食计划6个月。在干预前后，对每个个体测量两次体重、体脂（BF）百分比（BF%）、呼吸商（RQ）以及氧化还原状态标志物，即还原型谷胱甘肽（GSH）、硫代巴比妥酸反应性物质（TBARS）和蛋白质羰基（CARB）。饮食干预导致体重减轻、BF%降低和RQ下降。干预后GSH水平显著降低，而TBARS和CARB水平未受影响。根据初始GSH水平，将患者分为以下两组：高GSH组（GSH，>3.5 µmol/g Hb）和低GSH组（GSH <3.5 µmol/g Hb）。高GSH水平的患者体重和BF减轻更为明显。观察到GSH值高的MetS和肥胖患者对饮食治疗反应更好，体重和BF%变化更为显著。这一发现强调了在患有MetS的肥胖患者中识别氧化还原状态标志物，尤其是GSH的重要性。了解GSH水平可能有助于为希望减肥的个体制定更好的个性化饮食计划。
