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老年大鼠的空间记忆缺陷：通过胆碱乙酰转移酶评估胆碱能系统的作用。

Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT.

作者信息

Luine V, Hearns M

机构信息

Department of Psychology, Hunter College, City University of New York, NY 10021.

出版信息

Brain Res. 1990 Jul 23;523(2):321-4. doi: 10.1016/0006-8993(90)91507-d.

DOI:10.1016/0006-8993(90)91507-d
PMID:2400918
Abstract

Activity of choline acetylase (ChAT) was measured in basal forebrain cholinergic nuclei and in projection sites of these cells in the hippocampus and cortex of young rats and of aged rats who showed impaired performance on the radial arm maze. Decreased ChAT activity was found in the vertical diagonal band nucleus, the dentate gyrus and striatum of aged rats.

摘要

在年轻大鼠以及在放射状臂迷宫任务中表现受损的老年大鼠的海马体和皮质中，测量了基底前脑胆碱能核及其这些细胞投射部位的胆碱乙酰转移酶（ChAT）活性。在老年大鼠的垂直对角带核、齿状回和纹状体中发现ChAT活性降低。

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