Bernard J F, Huang G F, Besson J M
Unité de Recherche de Physiopharmacologie du Système Nerveux, I.N.S.E.R.M. U.161, Paris, France.
Brain Res. 1990 Jul 23;523(2):347-50. doi: 10.1016/0006-8993(90)91512-f.
Neurons (n = 107) were recorded, in anaesthetized rats, with extracellular micropipettes, in the nucleus centralis of the amygdala (Ce). The activity of a large majority (77%) was exclusively or preferentially affected by noxious stimuli applied in any area of the body. The rest of the neurons was not activated by any stimuli (21%) or responded only to innocuous stimuli (2%). The nociceptive neurons were classified into two groups: the neurons in the first group (34% of the whole population) were activated by mechanical and thermal noxious stimuli; the neurons in the second group (43% of the whole population) were inhibited by noxious stimuli. Neurons in two groups precisely encoded thermal stimuli in the noxious range. Transcutaneous electrical stimulation suggested that the Ce nociceptive neurons were under the influence of A delta and C fibers. These results demonstrate important nociceptive input to the Ce which according to previous studies probably relays in the pontine parabrachial nucleus. In addition, they are in good agreement with the involvement of the amygdala in emotional, autonomic and/or behavioral reactions to noxious events.
在麻醉大鼠中，用细胞外微电极在杏仁核中央核（Ce）记录了107个神经元。绝大多数（77%）神经元的活动仅受或优先受施加于身体任何部位的有害刺激影响。其余神经元不受任何刺激激活（21%）或仅对无害刺激有反应（2%）。伤害性神经元分为两组：第一组神经元（占总数的34%）被机械性和热性有害刺激激活；第二组神经元（占总数的43%）被有害刺激抑制。两组神经元都精确编码有害范围内的热刺激。经皮电刺激表明Ce伤害性神经元受Aδ纤维和C纤维影响。这些结果证明有重要的伤害性传入至Ce，根据先前研究，其可能在脑桥臂旁核中继。此外，这些结果与杏仁核参与对有害事件的情绪、自主和/或行为反应高度一致。
