Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
JPEN J Parenter Enteral Nutr. 2013 Sep;37(5 Suppl):51S-65S. doi: 10.1177/0148607113493326.
The search to improve outcomes in critically ill patients through nutrition support has steadily progressed over the past 4 decades. One current approach to this problem is the addition of specific nutrients as primary therapy to improve host defenses and improve the outcome of critically ill patients. The field is referred to as "pharmaconutrition," with the hope of focusing investigations on each nutrient to understand its pharmacological effects on immune and clinical outcomes. The purpose of this review is to describe some of the known physiological mechanisms of pharmaconutrients such as glutamine, arginine, ω-3 fatty acids, and selenium.
在过去的 40 年中，人们一直在努力通过营养支持来改善危重症患者的预后。目前解决这个问题的一种方法是添加特定的营养素作为主要治疗方法，以改善宿主防御能力，提高危重症患者的预后。该领域被称为“药物营养”，希望将研究重点放在每种营养素上，以了解其对免疫和临床结果的药理作用。本文旨在描述一些药物营养素（如谷氨酰胺、精氨酸、ω-3 脂肪酸和硒）的已知生理机制。
