Ajani J A, Welch S R, Raber M N, Fields W S, Krakoff I H
Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Cancer Invest. 1990;8(2):147-59. doi: 10.3109/07357909009017560.
Methods of assessing and reporting toxic reactions induced by therapy, particularly chemotherapy, need improvements. Accurate and reliable reporting of therapy-induced toxicity will be necessary for quality clinical research including drug development and for implementation of complex multimodality treatments, currently, however, the extent and quality of reporting of toxic reactions vary widely. Whereas standard and widely accepted criteria have been established for assessing and reporting therapeutic response, no such criteria exist for toxicity. We have developed comprehensive criteria for assessing and reliably reporting toxic reactions. We have reduced the degree of subjectivity in assigning grades by using primarily objective methods. An attempt has been made to standardize the "morbidity impact" of each toxicity grade irrespective of the organ system involved.
评估和报告治疗（尤其是化疗）引起的毒性反应的方法需要改进。准确可靠地报告治疗引起的毒性对于包括药物开发在内的高质量临床研究以及复杂多模式治疗的实施至关重要。然而，目前毒性反应报告的范围和质量差异很大。虽然已经建立了用于评估和报告治疗反应的标准且被广泛接受的标准，但对于毒性却没有这样的标准。我们已经制定了用于评估和可靠报告毒性反应的综合标准。我们主要通过使用客观方法降低了分级时的主观程度。已尝试对每个毒性等级的“发病影响”进行标准化，而不考虑涉及的器官系统。
