犬脑动脉中多巴胺和去甲肾上腺素的区域性分布——交感神经节前或节后神经切断的影响。

Regional distribution of dopamine and norepinephrine in canine cerebral arteries--effect of pre- or postganglionic sympathetic denervation.

机构信息

Department of Neurosurgery, Nagoya University School of Medicine, Nagoya 466, Japan.

出版信息

Brain Res. 1983 Jan 3;258(1):53-8. doi: 10.1016/0006-8993(83)91225-8.

Abstract

The regional distribution of dopamine (DA) and norepinephrine (NE) was investigated in dog cerebral arteries using high performance liquid chromatography with electrochemical detection. The distribution patterns of these two amines differed and there was a wide fluctuation in the ratio between the amounts of DA and NE. The ratios of DA to NE in the anterior cerebral artery and the anterior inferior cerebellar artery were 2-4 times higher than in the basilar or middle cerebral arteries, thereby suggesting that DA plays a role other than that of precursor of NE. The concentrations of both amines following pre- or postganglionic sympathetic denervation (superior cervical ganglion) were investigated. After preganglionic denervation (decentralization), neither amine showed significant changes in concentration. Postganglionic denervation one week prior to sacrifice resulted in a reduction in the concentrations of both amines; however, decrease in the former was less. These results suggest that the origin of dopamine in the cerebral arteries differs from that of the sympathetic nerves, via the superior cervical ganglion.

摘要

采用高效液相色谱电化学检测法研究了狗脑动脉中多巴胺（DA）和去甲肾上腺素（NE）的区域分布。这两种胺的分布模式不同，DA 和 NE 的含量比例波动很大。在前脑动脉和小脑前下动脉中，DA 与 NE 的比值是基底动脉或大脑中动脉的 2-4 倍，这表明 DA 除了是 NE 的前体之外，还具有其他作用。还研究了交感神经节前或节后（颈上神经节）去神经支配后这两种胺的浓度。节前去神经支配（去神经支配）后，两种胺的浓度均无明显变化。在牺牲前一周进行节后去神经支配后，两种胺的浓度均降低；但是，前者的减少程度较小。这些结果表明，通过颈上神经节，脑动脉中的多巴胺的来源不同于交感神经。