Suzuki Y, Ogura K, Shibuya M, Okada T, Kageyama N, Yamamoto I, Hara M
Department of Neurosurgery, Nagoya University, Japan.
Acta Neurochir (Wien). 1987;87(1-2):58-62. doi: 10.1007/BF02076018.
Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). The concentrations of these substances, which were assayed by high performance liquid chromatography (HPLC), were the highest on days 3 or 4, and thereafter showed a gradual decrease with an increase in time. The cisternal CSF in patients who had severe preoperative clinical grades of SAH or vasospasm contained relatively higher concentrations of HVA, 5-HIAA and TRP than those contained in patients who did not. It is proposed that SAH stimulates the release of monoamines from the brain with the resultant extracellular accumulation of their metabolites and their diffusion into CSF during the acute stage. This stimulatory effect of SAH on the brain monoamine system may be consistent with those previously reported in cases of cerebral haemorrhage or infarction.
对20例蛛网膜下腔出血（SAH）后3天内接受出血性动脉瘤手术夹闭的患者，测定其基底池脑脊液中的高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和色氨酸（TRP）。这些物质通过高效液相色谱法（HPLC）测定，其浓度在第3天或第4天最高，此后随时间推移逐渐下降。术前SAH临床分级严重或发生血管痉挛的患者，其脑池脑脊液中HVA、5-HIAA和TRP的浓度比未发生这些情况的患者相对更高。有人提出，SAH在急性期刺激大脑单胺释放，导致其代谢产物在细胞外积聚并扩散到脑脊液中。SAH对脑单胺系统的这种刺激作用可能与先前报道的脑出血或脑梗死病例中的作用一致。
