内毒素刺激下大鼠脑区中免疫反应性血管加压素浓度的变化。

Changes in immunoreactive vasopressin concentrations in brain regions of the rat in response to endotoxin.

机构信息

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Brain Res. 1983 Jan 3;258(1):127-32. doi: 10.1016/0006-8993(83)91237-4.

Abstract

The purpose of this investigation was to examine the changes in brain vasopressin (AVP) concentrations induced by endotoxin in the rat. Thirteen areas of the brain and the plasma were extracted and assayed for AVP under control conditions and at two times after endotoxin, 60 min (hypothermic phase) and 330 min (hyperthermic phase). There were no changes in AVP concentrations in the neurohypophysis, median eminence, supraoptic nucleus, paraventricular nucleus, suprachiasmatic nucleus, hippocampus or brainstem (nucleus of solitary tract). Decreased concentrations occurred at 330 min post-endotoxin in the lateral septum, medial septum, amygdala and caudate whereas increases occurred in the preoptic/anterior hypothalamus and cerebellum. Plasma levels increased by 60 min post-endotoxin and were still elevated by 330 min post-endotoxin. Endotoxin induces changes in AVP concentrations in several areas of brain, which may reflect alterations in turnover, perhaps related to the febrile rise in body temperature.

摘要

本研究旨在探讨内毒素诱导大鼠脑血管加压素（AVP）浓度的变化。在对照条件下和内毒素后 60 分钟（低温相）和 330 分钟（高温相）两次提取脑和血浆的 13 个区域，并测定 AVP。神经垂体、中脑结节、视上核、室旁核、视交叉上核、海马体或脑干（孤束核）中的 AVP 浓度没有变化。在侧隔核、中隔核、杏仁核和尾状核中，内毒素后 330 分钟时浓度降低，而在视前/下丘脑前部和小脑中浓度增加。内毒素后 60 分钟血浆水平升高，内毒素后 330 分钟仍升高。内毒素可引起大脑多个区域 AVP 浓度的变化，这可能反映了周转率的改变，可能与体温升高有关。