University of Virginia School of Medicine, Department of Pharmacology, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
Brain Res. 1983 Jan 3;258(1):159-64. doi: 10.1016/0006-8993(83)91244-1.
Long-term potentiation (LTP) of CA1 population spikes was elicited by cCA3 stimulation. Phencyclidine (PCP) and ketamine blocked the potentiation in a dose-dependent manner while diazepam and sodium thiopental had no effect. In midcollicular-transected rats where PCP has no depressant effect on the population spike, the drug still blocked LTP.
长时程增强（LTP）的 CA1 群体峰被 cCA3 刺激引发。苯环利定（PCP）和氯胺酮以剂量依赖的方式阻断了这种增强作用，而地西泮和硫喷妥钠则没有影响。在中脑横切大鼠中，PCP 对群体峰没有抑制作用，而这种药物仍然可以阻断 LTP。
