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[降香化学成分、药理机制及药代动力学研究进展]

[Advance in studies on chemical constitutions, pharmacological mechanism and pharmacokinetic profile of dalbergiae odoriferae lignum].

作者信息

Yang Zhi-Hong, Mei Chao, He Xue-Hui, Sun Xiao-Bo

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(11):1679-83.

Abstract

Dalbergiae Odoriferae Lignum is a traditional Chinese medicine (TCM) commonly used for promoting blood circulation, relieving pain and removing blood stasis. Volatile oil and flavonoid compounds are two main chemical constituents of Dalbergiae Odoriferae Lignum. Modern pharmacological studies show that Dalbergiae Odoriferae Lignum has many effects, such as relaxing blood, increasing blood flow of coronary, anti-oxidation, anti-inflammation and antitumor. Dalbergiae Odoriferae Lignum, as a characteristic TCM with the potential of further development, is generally compatible with other TCMs to treat cardio-cerebral vascular diseases. This article summarizes studies on chemical composition, pharmacological action, pharmacokinetic procfile in vivo and TCM compatibility in recent years, in order to provide references for further studies.

摘要

降香是一种常用的促进血液循环、止痛化瘀的传统中药。挥发油和黄酮类化合物是降香的两种主要化学成分。现代药理研究表明,降香具有多种作用,如舒张血管、增加冠脉血流量、抗氧化、抗炎和抗肿瘤等。降香作为一种具有进一步开发潜力的特色中药,通常与其他中药配伍用于治疗心脑血管疾病。本文综述了近年来降香的化学成分、药理作用、体内药代动力学及中药配伍的研究,以期为进一步研究提供参考。

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